Lecture
Integrated lab-on-a-chip devices as core unit of future self-driving laboratories?
- 09.04.2024 at 15:00 - 15:30
- ICM Saal 4b
- Language: English
- Type: Lecture
Lecture description
The miniaturisation of chemical functional elements, such as reactors and analysers, has opened up a new frontier in the field of chemistry.
Digital Microfluidics (DMF): DMF is a revolutionary approach that allows for the electrical control of chemical processes. This technology enables the manipulation of discrete microdroplets on an array of electrodes coated with a hydrophobic insulator. By applying a voltage to these electrodes, droplets can be moved, merged, mixed, or split, allowing for a wide range of chemical reactions to be performed on a single chip. Furthermore, the integration of mass spectrometry allows for real-time analysis of these reactions, providing unprecedented control and insight into the chemical processes [1].
Coupling of Droplet Microfluidics and Mass Spectrometry: The combination of droplet microfluidics and mass spectrometry offers a powerful tool for the study of whole cell catalysis. Droplet microfluidics allows for the encapsulation of individual cells within discrete droplets, enabling the study of single-cell reactions. The integration of mass spectrometry provides real-time analysis of these reactions, allowing for the monitoring of whole cell catalysis at the single cell level [3].
These integrated lab-on-a-chip devices are not only resource-efficient and rapid, but they also serve as a key enabling technology for AI-driven autonomous chemistry labs. As such, they are poised to become the core unit of the self-driving laboratories of the future, propelling the next generation of chemical discovery bots. This presentation will delve into the potential of these technologies and their implications for the future of chemical research.
Literature:
[1] A. Das, C. Weise, M. Polack, R. D. Urban, B. Krafft, S. Hasan, H. Westphal, R. Warias, S. Schmidt, T. Gulder, D. Belder, J. Am. Chem. Soc. 2022, 144, 23, 10353–10360. [2] K. Wink, M. van der Loh, N. Hartner, M. Polack, C. Dusny, A. Schmid, D. Belder, Angew. Chem. Int. Ed. 2022, 61, e202204098.
Digital Microfluidics (DMF): DMF is a revolutionary approach that allows for the electrical control of chemical processes. This technology enables the manipulation of discrete microdroplets on an array of electrodes coated with a hydrophobic insulator. By applying a voltage to these electrodes, droplets can be moved, merged, mixed, or split, allowing for a wide range of chemical reactions to be performed on a single chip. Furthermore, the integration of mass spectrometry allows for real-time analysis of these reactions, providing unprecedented control and insight into the chemical processes [1].
Coupling of Droplet Microfluidics and Mass Spectrometry: The combination of droplet microfluidics and mass spectrometry offers a powerful tool for the study of whole cell catalysis. Droplet microfluidics allows for the encapsulation of individual cells within discrete droplets, enabling the study of single-cell reactions. The integration of mass spectrometry provides real-time analysis of these reactions, allowing for the monitoring of whole cell catalysis at the single cell level [3].
These integrated lab-on-a-chip devices are not only resource-efficient and rapid, but they also serve as a key enabling technology for AI-driven autonomous chemistry labs. As such, they are poised to become the core unit of the self-driving laboratories of the future, propelling the next generation of chemical discovery bots. This presentation will delve into the potential of these technologies and their implications for the future of chemical research.
Literature:
[1] A. Das, C. Weise, M. Polack, R. D. Urban, B. Krafft, S. Hasan, H. Westphal, R. Warias, S. Schmidt, T. Gulder, D. Belder, J. Am. Chem. Soc. 2022, 144, 23, 10353–10360. [2] K. Wink, M. van der Loh, N. Hartner, M. Polack, C. Dusny, A. Schmid, D. Belder, Angew. Chem. Int. Ed. 2022, 61, e202204098.
All lectures within this session
- 15:00 - 15:30Integrated lab-on-a-chip devices as core unit of future self-driving laboratories?
- 15:30 - 16:00Enabling data-science in the laboratory with open formats and infrastructure
- 16:00 - 16:30On the road of digital transformation: Building the fully automated and digitalized lab of the future
- 16:30 - 17:00High-throughput analysis on open droplet arrays