Lecture
Mid-Infrared Arthroscopy: Real-Time In-Vivo Cartilage Condition Assessment
- 11.04.2024 at 12:30 - 13:00
- ICM Saal 5
- Language: English
- Type: Lecture
Lecture description
Owing to the recent technological advances in mid-infrared (3-15 μm; MIR) laser technology, especially cascade laser spectroscopy (CSL) has evolved into a state-of-the-art tool for the selective and sensitive quantification of trace analytes in liquid, solid, and gaseous state in a wide variety of sensing scenarios. High output power, narrow linewidths, single-mode operation, low power consumption, broad tunability and compact dimensions are just some of the most outstanding features of cascade lasers.
Since their introduction in the mid 1990ies, quantum cascade lasers (QCL) and interband cascade lasers (ICL) have rapidly matured into the probably most important contemporary MIR laser light sources. In this presentation, we will discuss state-of-the-art sensing platforms that benefit from cascade lasers combined with miniaturized photonic platforms providing direct access to molecule-specific information. Indeed, point-of-care diagnostics in clinical settings are becoming more prevalent taking advantage of the fact that MIR detection schemes do not require reagents or labeled constituents, and therefore facilitate localized on-site analysis close to real-time.
With increasing progress towards highly miniaturized MIR optical components, evidently devices useful in medical/clinical applications may directly capitalize on advantageous features of integrated MIR photonics. Quo vadis? For sure, in-vivo applications enabling direct sensing and/or condition monitoring within living organisms are considered the ‘holy grail’. We will highlight the utility of MIR catheter technologies for analyzing cartilage damage in-vivo during arthroscopic surgery, and discuss potential and challenges when translating this technology into clinical practice.
[1] P. Krebs, M. Nägele, P. Fomina, V. Virtanen, E. Nippolainen, R. Shaikh, I.O. Afara, J. Töyräs, I. Usenov, T. Sakharova, V. Artyushenko, V. Tafintseva, J.H. Solheim, B. Zimmermann, A. Kohler, O. König, S. Saarakkala, B. Mizaikoff, Laser-Irradiating Infrared Attenuated Total Reflection Spectroscopy of Articular Cartilage: Potential and Challenges for Diagnosing Osteoarthritis, Osteoarthritis and Cartilage Open, in press (2024)
[2] V. Virtanen, V. Tafintseva, R. Shaikh, E. Nippolainen, J. Haas, J. Töyräs, H. Kröger, J. Solheim, B. Zimmermann, A. Kohler, B. Mizaikoff, M. Finnilä, L. Rieppo, S. Saarakkala, Infrared Spectroscopy is Suitable for Objective Assessment of Articular Cartilage Health, Osteoathritis and Cartilage Open, 4, 100250: 1-7 (2022)
[3] I. Vasilikos, R. Roelz, C. Scholz, B. Mizaikoff, K. Argiti, R. Watzlawick Ralf, G.‐C. Giagkos, E. M. Fragkakis, S. Ghanaati, J. Beck, U. Hubbe, Autologous Platelet‐Rich Fibrin (PRF) Augmentation as an Add‐On Therapy in Deep Surgical Site Infections (dSSIs) after Instrumented Spinal Surgery: Preliminary Results of a Single Institution Case Series, Acta Neurochirurgica, 163, 2761-2767 (2021)
[4] D. Warnecke, J. Balko, J. Haas, R. Bieger, F. Leucht, N. Wolf, N. Schild, S. Stein, A. Ignatius, H. Reichel, B. Mizaikoff, L. Dürselen, Degeneration Alters the Biomechanical Properties and Structural Composition of Meniscal Tissue, Osteoarthritis and Cartilage, 28, 1482-1491 (2020)
[5] I. Vasilikos, G. Q. Teixeira, A. Seitz, J. Nothelfer, J. Haas, H.-J. Wilke, B. Mizaikoff, J. Beck, U. Hubbe, C. Neidlinger-Wilke, Can UVA-Light-Activated Riboflavin-Induced Collagen Crosslinking be Transferred from Ophthalmology to Spine Surgery? A Feasibility Study on Bovine Intervertebral Disc, PLOS ONE 16, e0252672: 1-15 (2021)
[6] I. Vasilikos, J. Haas, G. Q. Teixeira, J. Nothelfer, C. Neidlinger-Wilke, H. Wilke, A. Seitz, D. G. Vavvas, J. Zentner, J. Beck, U. Hubbe, B. Mizaikoff, Infrared attenuated total reflection spectroscopic surface analysis of bovine-tail intervertebral discs after UV-light-activated riboflavin-induced collagen cross-linking, Journal of Biophotonics 13, e202000110 (2020)
[7] A. Lopez-Lorente, P. Wang, B. Mizaikoff, S. Stein, J. Balko, L. Durselen, R. Lu, Surface analysis of sheep menisci after meniscectomy via infrared attenuated total reflection spectroscopy, Journal of Biophotonics e201800429 (2019)
[8] Á.I. López-Lorente, B. Mizaikoff, Mid-infrared spectroscopy for protein analysis: potential and challenges, Analytical and Bioanalytical Chemistry, 408 (11), 2875–2889 (2016), DOI: 10.1007/s00216-016-9375-5
[9] B. Mizaikoff, Waveguide-Enhanced Mid-Infrared Chem/Bio Sensors, Chemical Society Reviews, 42 (22), 8683–8699 (2013)
Since their introduction in the mid 1990ies, quantum cascade lasers (QCL) and interband cascade lasers (ICL) have rapidly matured into the probably most important contemporary MIR laser light sources. In this presentation, we will discuss state-of-the-art sensing platforms that benefit from cascade lasers combined with miniaturized photonic platforms providing direct access to molecule-specific information. Indeed, point-of-care diagnostics in clinical settings are becoming more prevalent taking advantage of the fact that MIR detection schemes do not require reagents or labeled constituents, and therefore facilitate localized on-site analysis close to real-time.
With increasing progress towards highly miniaturized MIR optical components, evidently devices useful in medical/clinical applications may directly capitalize on advantageous features of integrated MIR photonics. Quo vadis? For sure, in-vivo applications enabling direct sensing and/or condition monitoring within living organisms are considered the ‘holy grail’. We will highlight the utility of MIR catheter technologies for analyzing cartilage damage in-vivo during arthroscopic surgery, and discuss potential and challenges when translating this technology into clinical practice.
[1] P. Krebs, M. Nägele, P. Fomina, V. Virtanen, E. Nippolainen, R. Shaikh, I.O. Afara, J. Töyräs, I. Usenov, T. Sakharova, V. Artyushenko, V. Tafintseva, J.H. Solheim, B. Zimmermann, A. Kohler, O. König, S. Saarakkala, B. Mizaikoff, Laser-Irradiating Infrared Attenuated Total Reflection Spectroscopy of Articular Cartilage: Potential and Challenges for Diagnosing Osteoarthritis, Osteoarthritis and Cartilage Open, in press (2024)
[2] V. Virtanen, V. Tafintseva, R. Shaikh, E. Nippolainen, J. Haas, J. Töyräs, H. Kröger, J. Solheim, B. Zimmermann, A. Kohler, B. Mizaikoff, M. Finnilä, L. Rieppo, S. Saarakkala, Infrared Spectroscopy is Suitable for Objective Assessment of Articular Cartilage Health, Osteoathritis and Cartilage Open, 4, 100250: 1-7 (2022)
[3] I. Vasilikos, R. Roelz, C. Scholz, B. Mizaikoff, K. Argiti, R. Watzlawick Ralf, G.‐C. Giagkos, E. M. Fragkakis, S. Ghanaati, J. Beck, U. Hubbe, Autologous Platelet‐Rich Fibrin (PRF) Augmentation as an Add‐On Therapy in Deep Surgical Site Infections (dSSIs) after Instrumented Spinal Surgery: Preliminary Results of a Single Institution Case Series, Acta Neurochirurgica, 163, 2761-2767 (2021)
[4] D. Warnecke, J. Balko, J. Haas, R. Bieger, F. Leucht, N. Wolf, N. Schild, S. Stein, A. Ignatius, H. Reichel, B. Mizaikoff, L. Dürselen, Degeneration Alters the Biomechanical Properties and Structural Composition of Meniscal Tissue, Osteoarthritis and Cartilage, 28, 1482-1491 (2020)
[5] I. Vasilikos, G. Q. Teixeira, A. Seitz, J. Nothelfer, J. Haas, H.-J. Wilke, B. Mizaikoff, J. Beck, U. Hubbe, C. Neidlinger-Wilke, Can UVA-Light-Activated Riboflavin-Induced Collagen Crosslinking be Transferred from Ophthalmology to Spine Surgery? A Feasibility Study on Bovine Intervertebral Disc, PLOS ONE 16, e0252672: 1-15 (2021)
[6] I. Vasilikos, J. Haas, G. Q. Teixeira, J. Nothelfer, C. Neidlinger-Wilke, H. Wilke, A. Seitz, D. G. Vavvas, J. Zentner, J. Beck, U. Hubbe, B. Mizaikoff, Infrared attenuated total reflection spectroscopic surface analysis of bovine-tail intervertebral discs after UV-light-activated riboflavin-induced collagen cross-linking, Journal of Biophotonics 13, e202000110 (2020)
[7] A. Lopez-Lorente, P. Wang, B. Mizaikoff, S. Stein, J. Balko, L. Durselen, R. Lu, Surface analysis of sheep menisci after meniscectomy via infrared attenuated total reflection spectroscopy, Journal of Biophotonics e201800429 (2019)
[8] Á.I. López-Lorente, B. Mizaikoff, Mid-infrared spectroscopy for protein analysis: potential and challenges, Analytical and Bioanalytical Chemistry, 408 (11), 2875–2889 (2016), DOI: 10.1007/s00216-016-9375-5
[9] B. Mizaikoff, Waveguide-Enhanced Mid-Infrared Chem/Bio Sensors, Chemical Society Reviews, 42 (22), 8683–8699 (2013)
All lectures within this session
- 12:30 - 13:00Mid-Infrared Arthroscopy: Real-Time In-Vivo Cartilage Condition Assessment
- 13:00 - 13:30Advances in Quantitative Bioimaging of Nanomaterials using LA-ICP-MS: Implications for Nanotoxicology
- 13:30 - 14:00Advancements in environmental metal speciation analysis by multi modal mass spectrometry
- 14:00 - 14:30Advancing X-ray Fluorescence Spectrometry for (Trace) Element Determination in Biomedical Samples and Energy Materials