Lecture
New Possibilities for the Discovery of Disease Relevant Information. Gaining a new Picture of Biology with Single Cell and Spatial Analyses
- 11.04.2024 at 14:00 - 14:30
- ICM Saal 2
- Language: English
- Type: Lecture
Lecture description
The integration of single cell sequencing, spatial transcriptomic data and targeted in- situ analyses, particularly in FFPE cancer samples, has the potential to expedite the elucidation of molecular patterns essential for understanding various disease relevant contexts, such as the tumor microenvironment or inflammatory processes in neurodegenerative diseases. Based on a scientific example [1] this presentation will highlight how these technologies, both individually and synergistically, unveil molecular signatures crucial for comprehending disease mechanisms, leveraging the distinct advantages of each technology as well as showing the synergies to provide new insights into disease-relevant processes. Literature:
[1] Janesick A, Shelansky R, Gottscho AD, et al. High resolution mapping of the tumor microenvironment using integrated single-cell, spatial and in situ analysis. Nat Commun. 2023;14(1):8353. Published 2023 Dec 19. doi:10.1038/s41467-023-43458-x
[1] Janesick A, Shelansky R, Gottscho AD, et al. High resolution mapping of the tumor microenvironment using integrated single-cell, spatial and in situ analysis. Nat Commun. 2023;14(1):8353. Published 2023 Dec 19. doi:10.1038/s41467-023-43458-x
All lectures within this session
- 12:30 - 13:00From oncology to cardiology: Spatial omics technologies for topographic biomarker discovery
- 13:00 - 13:30From DNA Nanotechnology to biomedical insight: Towards single-molecule spatial omics
- 13:30 - 14:00Deciphering Metabolism in Host–Microbe Interactions with Mass spectrometry imaging and microscopy
- 14:00 - 14:30New Possibilities for the Discovery of Disease Relevant Information. Gaining a new Picture of Biology with Single Cell and Spatial Analyses