In early 1990’s, I proposed my concept of integrated chemistry on a chip. Based on success of preliminary experiments of the idea, I described the clear concept of the “integrated chemistry” and future implementation to analytical instruments and chemical plants in the application documents to a big funding program. It was my dream.
After I successfully got the funding program (Kanagawa Academy of Science and Technology KAST project) and further several projects continuously, I devoted myself to realize the concrete idea of the micro unit operation MUO and continuous flow chemical processing CFCP. Our microfluidic method of MUO+CFCP was very general methodology which was the first pressure driven and could integrate variety of analytical and synthesis chemical procedures.
Almost 30 years struggling, now, we are developing single cell sample level analysis at pico-liter to femto-liter volume by a nano/microfluidic device and desktop chemical plants at ton/year production volume by large scale serial-parallel combination of hundreds and thousands of microfluidic devices. My dream has come true.
In this lecture, I will describe the short history of our R&D, and introduce the on-going projects of the femto-liter MS sample interface for single cell proteomics, and the several hundred serial-parallel microfluidic device system for ton/year polymer production.
Literature:
[1] More than 300 papers and other kinds of information from our research group can be found in the following web-site. http://webpark1390.sakura.ne.jp/cms/?lang=en
Acknowledgements
A Part of this project is supported by the Crafoord Foundation of Sweden and the NSTC of Taiwan, and Daicel of Japan.
